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ドキシサイクリンの歯周ポケット内滲出液移行 河野誠之 １） 金子明寛 ２） |
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The drug concentration in the gingival crevicular fluid level after oral administration of doxycycline （DOXY） Masayuki KOUNO １）， Akihiro KANEKO ２） Abstract：Oral dose of 200mg doxycycline (DOXY) was administered before exodontia to 18 patients. The drug concentration of DOXY in the gingival crevicular fluid (GCF) was measured from 30 to 160 minutes after oral administration. The drug concentrations in the effusion from the exodontia wound and in saliva were also measured. As a result, 90% of MIC of DOXY against Porphyromonas gingivalis and Fusobacterium spp． was 0.25μg／mL, and 80% of MIC against Prevotella intermedia was 2μg／mL. The average drug level of DOXY in GCF was 2.4μg／mL, which is considered to be enough antibacterial concentration against pathological bacterial flora. In addition, the average drug concentrations in the effusion from the exodontias wound and in saliva were 1.62μg／mL and 0.24μg／mL, respectively. Key Words：ドキシサイクリン （Doxycycline （DOXY））、 歯周ポケット内滲出液 （Gingival crevicular fluid （GCF））、 薬剤濃度 （drug level）、 歯周炎 （Periodontitis） １） りそな銀行東京健康管理センター歯科診療所 （主任：河野誠之） ２） 東海大学医学部機能再建学系歯科口腔外科学部門 （主任：金子明寛教授） １） Dental Clinic (Tokyo) of RESONA Bank (Chief：Dr.Masayuki Kouno) ２） Department of Oral Surgery School of Medicine TOKAI University (Chief：prof.Akihiro Kaneko) 〔2003年７月23日受付、 2003年９月８日受理〕 |